 |
Indication & Dosage |
| |
| |
| Oral |
| UNCOMPLICATED LOWER URINARY TRACT INFECTIONS |
| Adult:
1 g 4 times daily for 1-2 wk. Long-term therapy: Reduce daily dose to 2 g. |
| |
| Oral |
| UNCOMPLICATED LOWER URINARY TRACT INFECTIONS |
| Child:
>3 mth: 50 mg/kg daily in 4 equally divided doses. Long-term therapy: Reduce dose to 30 mg/kg daily. Prophylaxis: 15 mg/kg bid |
| |
| Ophthalmic |
| SHIGELLOSIS |
| Adult:
1 g 4 times daily for 1-2 wk. Long-term therapy: Reduce daily dose to 2 g. |
| |
| Oral |
| SHIGELLOSIS |
| Child:
1 g 4 times daily for 1-2 wk. Long-term therapy: Reduce daily dose to 2 g. |
|
| |
|
| Administration |
Should be taken with food. |
| |
|
| Precautions |
Hepatic or moderate renal impairment, severe cerebral arteriosclerosis, G6PD deficiency. Monitor blood counts, renal and hepatic function for treatment >2 wk. Children <18 yr. Elderly. Avoid exposure to sunlight or sunlamps. Pregnancy and lactation. |
| |
|
Potentially Life-threatening
Adverse Drug Reactions |
Nausea, vomiting, diarrhoea, abdominal pain; photosensitivity reactions, allergic rash, urticaria, pruritus; visual disturbances, headache, dizziness or vertigo, drowsiness, confusion, depression, excitement, hallucinations, toxic psychoses or convulsions (especially after large doses), intracranial hypertension (especially in infants and young children), metabolic acidosis; peripheral neuropathies, muscular weakness, myalgia; arthralgia, tendon damage; cholestatic jaundice, thrombocytopenia, leucopenia. |
| |
|
| Adverse Drug Reactions |
Erythema multiforme and Stevens-Johnson syndrome; anaphylactoid reactions. Auto-immune haemolytic anaemia (particularly in elderly patients). |
| |
|
| Interactions |
Absorption reduced by sucralfate, and divalent and trivalent cations e.g. aluminium, calcium, iron, magnesium, zinc. Excretion reduced and plasma concentrations increased with probenecid. Reduced effects with chloramphenicol, nitrofurantoin, tetracycline. |
| |
|
|
|
